Do Postpartum Levels of Apolipoproteins Prospectively Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes Mellitus?

M Lappas; HM Georgiou; A Velagic; JC Willcox; M Permezel; A Shub

Journal article

Do Postpartum Levels of Apolipoproteins Prospectively Predict the Development of Type 2 Diabetes in Women with Previous Gestational Diabetes Mellitus?

M Lappas, HM Georgiou, A Velagic, JC Willcox, M Permezel, A Shub

Experimental and Clinical Endocrinology and Diabetes | JOHANN AMBROSIUS BARTH VERLAG MEDIZINVERLAGE HEIDELBERG GMBH | Published : 2019

DOI: 10.1055/a-0577-7700

Abstract

Aims The risk of developing type 2 diabetes is greater in women with previous gestational diabetes mellitus (GDM). Apolipoprotein (Apo) species have been associated with the development of type 2 diabetes in the general population. The aim of this study was to determine if circulating levels of Apo species can predict development of type 2 diabetes in women with previous GDM. Methods Apo AI, Apo AII, Apo B, Apo CII, Apo CIII and Apo E levels were measured in 95 women with normal glucose tolerance, 12 weeks following an index GDM pregnancy. Women were assessed for up to 10 years for the development of type 2 diabetes. Results Postpartum Apo CIII levels, and Apo CIII/Apo AI, Apo CIII/Apo AII, ..

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University of Melbourne Researchers

Martha Lappas Author

Harry Georgiou Author

Michael Permezel Author

Alexis Shub Author

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Grants

Awarded by Norman Beischer Medical Research Foundation

Funding Acknowledgements

ML is supported by a Career Development Fellowship from National Health and Medical Research Council (NHMRC; grant no. 1047025). The work described in this manuscript was funded by the Norman Beischer Medical Research Foundation (ML, AS, HMG).